Abstract:
:5'-Dipeptidyl derivatives of 5-fluorodeoxyuridine (FdU) (1a-d) were synthesized. These compounds are biologically inactive but can be activated by peptide deformylase, which removes the N-terminal formyl group of the dipeptide, to release the active drug FdU via an intramolecular cyclization reaction. Because the deformylase is ubiquitous among bacteria but absent in mammalian cells, 1a-d provide a novel class of potential antibacterial agents.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Wei Y,Pei Ddoi
10.1016/s0960-894x(00)00167-0subject
Has Abstractpub_date
2000-05-15 00:00:00pages
1073-6issue
10eissn
0960-894Xissn
1464-3405pii
S0960-894X(00)00167-0journal_volume
10pub_type
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