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Synthesis and insecticidal activity of new oxime derivatives of podophyllotoxin-based phenazines against Mythimna separata Walker.

Abstract：

:To discover new natural-product-based insecticidal agents, a series of novel oxime derivatives of podophyllotoxin-based phenazines modified in the C, D and E rings of podophyllotoxin were prepared and tested as insecticidal agents against the pre-third-instar larvae of oriental armyworm, Mythimna separata (Walker) in vivo at 1 mg/mL. The steric configuration of IIIc was unambiguously confirmed by single-crystal X-ray diffraction analysis. Compounds IIIa-d, and IIIi exhibited an equal or higher insecticidal activity than toosendanin.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Zhi X,Yang C,Yu X,Xu H

doi

10.1016/j.bmcl.2014.10.081

subject

Has Abstract

pub_date

2014-12-15 00:00:00

pages

5679-5682

issue

24

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)01152-4

journal_volume

24

pub_type

杂志文章

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