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Sulfamoyl benzamides as novel CB2 cannabinoid receptor ligands.

Abstract：

:Sulfamoyl benzamides were identified as a novel series of cannabinoid receptor ligands. Starting from a screening hit 8 that had modest affinity for the cannabinoid CB(2) receptor, a parallel synthesis approach and initial SAR are described, leading to compound 27 with 120-fold functional selectivity for the CB(2) receptor. This compound produced robust antiallodynic activity in rodent models of postoperative pain and neuropathic pain without traditional cannabinergic side effects.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Worm K,Zhou QJ,Saeui CT,Green RC,Cassel JA,Stabley GJ,DeHaven RN,Conway-James N,LaBuda CJ,Koblish M,Little PJ,Dolle RE

doi

10.1016/j.bmcl.2008.04.006

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

2830-5

issue

9

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)00396-X

journal_volume

18

pub_type

杂志文章

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