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Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I.

Abstract：

:The X-ray crystallographic structure for the adduct of an activator with human carbonic anhydrase isozyme I (hCA I) is reported. L-Histidine binds deep within the enzyme active site, participating in a network of hydrogen bonds involving its carboxylate moiety and the zinc-bound water molecule, as well as the imidazole of His200, being in van der Waals contacts with Thr199, His200, His64, and His67. This binding is very different from that to the other major cytosolic isozyme hCA II.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Temperini C,Scozzafava A,Supuran CT

doi

10.1016/j.bmcl.2006.07.021

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

5152-6

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00798-0

journal_volume

16

pub_type

杂志文章

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