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Developing potential Helicobacter pylori urease inhibitors from novel oxoindoline derivatives: Synthesis, biological evaluation and in silico study.

Abstract：

:By recruiting the important moiety from Shikonin, a series of novel oxoindoline derivatives S1-S20 have been synthesized for inhibiting H. pylori urease. The most potent compound S18 displayed better activity (IC50 = 0.71 μM; MIC = 0.48 μM) than the positive controls AHA (IC50 = 17.2 μM) and Metronidazole (MIC = 31.3 μM). With low cytotoxicity, it showed considerable potential for further development. Docking simulation revealed the possible binding pattern of this series. 3D QSAR model was built to discuss SAR and give useful hints for future modification.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Yang YS,Su MM,Zhang XP,Liu QX,He ZX,Xu C,Zhu HL

doi

10.1016/j.bmcl.2018.08.025

subject

Has Abstract

pub_date

2018-10-15 00:00:00

pages

3182-3186

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(18)30702-9

journal_volume

28

pub_type

杂志文章

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