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Kinetic delay of cyclization/elimination-coupled enzyme assays: analysis and solution.

Abstract：

:A kinetic analysis of an enzyme assay employing a synthetic substrate that produces a detectable signal through a spontaneous organic cyclization/elimination reaction following the enzymatic reaction was conducted. The results from the calculation were used to predict the lag period and provide accurate measurements of the activity of alkaline phosphatase using the fluorogenic substrate (1).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Xue F,Seto CT

doi

10.1016/j.bmcl.2010.09.104

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

1069-71

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01413-7

journal_volume

21

pub_type

杂志文章

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