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Synthesis and evaluation of potent pyrrolidine H(3) antagonists.

Abstract：

:The synthesis and biological evaluation of novel antagonists of the rat H(3) receptor are described. These compounds differ from prototypical H(3) antagonists in that they do not contain an imidazole moiety, but rather a substituted aminopyrrolidine moiety. A systematic modification of the substituents on the aminopyrrolidine ring was performed using pre-formatted precursor sets, where applicable, to afford several compounds with high affinity and selectivity for the H(3) receptor.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Vasudevan A,Conner SE,Gentles RG,Faghih R,Liu H,Dwight W,Ireland L,Kang CH,Esbenshade TA,Bennani YL,Hancock AA

doi

10.1016/s0960-894x(02)00685-6

subject

Has Abstract

pub_date

2002-11-04 00:00:00

pages

3055-8

issue

21

eissn

0960-894X

issn

1464-3405

pii

S0960894X02006856

journal_volume

12

pub_type

杂志文章

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