Abstract:
:A series of 1-adamantanecarboxamides was synthesized and examined for their potency as a selective 5-HT2 receptor antagonist. We found (S)-N-[1-[2-(4-fluorophenyl)ethyl]pyrrolidin-3-yl]-1-adamantane carboxamide hydrochloride hydrate (10-(S), Y-39241) to have a high affinity and selectivity for 5-HT2 receptors, and this potent anti-platelet effect of Y-39241 was confirmed both in vitro and in vivo.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Fujio M,Kuroita T,Sakai Y,Nakagawa H,Matsumoto Ydoi
10.1016/s0960-894x(00)00492-3subject
Has Abstractpub_date
2000-11-06 00:00:00pages
2457-61issue
21eissn
0960-894Xissn
1464-3405pii
S0960-894X(00)00492-3journal_volume
10pub_type
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