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Synthesis of N tau-arylhistidine derivatives via direct N-arylation.

Abstract：

:N(tau)-Aryl-histidine derivatives were synthesized using a modified one-step Cu-catalyzed coupling of aryl halides and N-acetylhistidine methyl ester. The latter is much less reactive than imidazole toward aryl halides. p-Chloroiodobenzene coupled with iodine displacement only, whereas m- and p-bromoiodobenzene both gave mixtures of bromo- and iodophenyl products.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Yue W,Lewis SI,Koen YM,Hanzlik RP

doi

10.1016/j.bmcl.2004.01.058

subject

Has Abstract

pub_date

2004-04-05 00:00:00

pages

1637-40

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960894X04001386

journal_volume

14

pub_type

杂志文章

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