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Synthesis and SAR study of tricyclic sulfones as γ-secretase inhibitors: C-6 and C-8 positions.

Abstract：

:SAR exploration at C-6 and C-8 positions of the tricyclic sulfone series was carried out. Several functional groups were found to be well tolerated at C-6 and C-8 positions. Selective combination of C-6 and C-8 modification resulted in new tricyclic sulfone analogs with efficacy in in vivo mouse Aβ(40) lowering model.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Su J,Tang H,McKittrick BA,Xu R,Clader JW,Greenlee WJ,Hyde L,Zhang L

doi

10.1016/j.bmcl.2011.03.094

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

3447-51

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)00423-9

journal_volume

21

pub_type

杂志文章

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