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Surface plasmon resonance-based detection of ladder-shaped polyethers by inhibition detection method.

Abstract：

:Ladder-shaped polyether (LSP) compounds represented by brevetoxins and ciguatoxins were largely discovered in association with seafood poisoning. Thus, a quick quantification method for LSPs is potentially important. We examined a surface plasmon resonance method using desulfated-yessotoxin (dsYTX) immobilized on a sensor chip and phosphodiesterase PDEII in a inhibition detection mode. Yessotoxin, brevetoxin B and synthetic LSP derivatives showed clear inhibition against PDEII binding to the immobilized dsYTX, by which their half inhibitory concentrations were successfully estimated. This inhibition method appeared to be superior in specificity to direct binding assays where binding proteins to LSP was immobilized on a sensor chip.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Mouri R,Oishi T,Torikai K,Ujihara S,Matsumori N,Murata M,Oshima Y

doi

10.1016/j.bmcl.2009.03.103

subject

Has Abstract

pub_date

2009-05-15 00:00:00

pages

2824-8

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)00408-9

journal_volume

19

pub_type

杂志文章

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