Abstract:
:The preparation and structure-activity-relationships of novel pyrrolidine-carboxamides and oxadiazoles are described. Compounds in this series were found to be potent hNK(1) antagonists in vitro and efficacious in vivo with minimal interactions with P(450) liver enzymes. Oxadiazole analog 22 was determined to have excellent hNK(1) binding affinity, functional activity, and a good PD response in vivo.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Young JR,Eid R,Turner C,DeVita RJ,Kurtz MM,Tsao KL,Chicchi GG,Wheeldon A,Carlson E,Mills SGdoi
10.1016/j.bmcl.2007.08.028subject
Has Abstractpub_date
2007-10-01 00:00:00pages
5310-5issue
19eissn
0960-894Xissn
1464-3405pii
S0960-894X(07)00977-8journal_volume
17pub_type
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