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Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051.

Abstract：

:The same two major CYP mediated metabolites of DG-051 were produced in the presence of rat, dog, monkey and human liver microsomes. Their respective structures were hypothesized based on mass spectrometry data correlated with the parent structure and confirmed by comparison with authentic synthetic samples. The number of regioisomers synthesized as candidates for metabolite M1 was narrowed down using a metabolic study of a selectively deuterated DG-051 analogue.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Enache LA,Zhang J,Sullins DW,Kennedy I,Onua E,Zembower DE,Muellner FW,Singh J,Kiselyov AS

doi

10.1016/j.bmcl.2009.09.097

subject

Has Abstract

pub_date

2009-11-15 00:00:00

pages

6275-9

issue

22

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)01365-1

journal_volume

19

pub_type

杂志文章

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