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Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis.

Abstract：

:A total of 106 nitric oxide-releasing derivatives of oleanolic acid were synthesized and their effects on the inhibition of anti-Fas-mediated HepG2 cell apoptosis were evaluated in vitro. Several compounds inhibited anti-Fas-mediated HepG2 cell apoptosis in a dose-dependent manner. Within this series of compounds, 8b is the most potent inhibitor. The development of new NO-releasing derivatives of oleanolic acid may aid in the design of NO-based medicines for the intervention of human liver inflammatory diseases.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Chen L,Zhang Y,Kong X,Peng S,Tian J

doi

10.1016/j.bmcl.2007.03.068

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

2979-82

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00371-X

journal_volume

17

pub_type

杂志文章

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