Abstract:
:Aryldihydropyridazinones and aryldimethylpyrazolones with 2-benzyl vinylogous amide substituents have been identified as potent PDE3B subtype selective inhibitors. Dihydropyridazinone 8a (PDE3B IC(50)=0.19 nM, 3A IC(50)=1.3 nM) was selected for in vivo evaluation of lipolysis induction, metabolic rate increase, and cardiovascular effects.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Edmondson SD,Mastracchio A,He J,Chung CC,Forrest MJ,Hofsess S,MacIntyre E,Metzger J,O'Connor N,Patel K,Tong X,Tota MR,Van der Ploeg LH,Varnerin JP,Fisher MH,Wyvratt MJ,Weber AE,Parmee ERdoi
10.1016/j.bmcl.2003.08.056subject
Has Abstractpub_date
2003-11-17 00:00:00pages
3983-7issue
22eissn
0960-894Xissn
1464-3405pii
S0960894X03009181journal_volume
13pub_type
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