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Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004.

Abstract：

:New heteroarylcarboxamide head groups substituted with two aromatic rings analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent inhibitors of RON tyrosine kinase with various level of selectivity for c-Met RTK were obtained.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Raeppel F,Raeppel SL,Therrien E

doi

10.1016/j.bmcl.2015.07.080

subject

Has Abstract

pub_date

2015-09-15 00:00:00

pages

3810-5

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)00784-2

journal_volume

25

pub_type

杂志文章

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