Synthesis of β-boswellic acid derivatives as cytotoxic and apoptotic agents.

Abstract:

:A series of β-boswellic acid derivatives were synthesized and evaluated for anticancer activity. One of the lead analog 4f displayed significant anticancer activity against a panel of cancer cells as well as substantially inhibited colony formation in HCT-116 cells. Furthermore, 4f was found to be a potent inducer of apoptosis confirmed by loss of mitochondrial membrane potential, DAPI staining, Western blotting and ROS generation.

journal_name

Bioorg Med Chem Lett

authors

Kumar A,Qayum A,Sharma PR,Singh SK,Shah BA

doi

10.1016/j.bmcl.2015.11.027

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

76-81

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)30236-5

journal_volume

26

pub_type

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