Synthesis and anti-leishmanial activity of 1-aryl-β-carboline derivatives against Leishmania donovani.

Abstract:

:β-carbolines from various natural and synthetic sources have been known to show diverse biological activities. As a part of our current ongoing project to search for potent natural product-derived anti-leishmanial compounds, we have synthesized a series of substituted 1-aryl-β-carboline derivatives. A total of 22 compounds were synthesized and tested in vitro against Leishmania donovani, out of which 6 compounds (4, 5, 10, 11, 19 and 22) showed notably more activity than the standard miltefosine (IC(50) 12.07±0.82 μM), with compound 4 being the most potent (IC(50) 2.16±0.26 μM).

journal_name

Bioorg Med Chem Lett

authors

Gohil VM,Brahmbhatt KG,Loiseau PM,Bhutani KK

doi

10.1016/j.bmcl.2012.04.115

subject

Has Abstract

pub_date

2012-06-15 00:00:00

pages

3905-7

issue

12

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00574-4

journal_volume

22

pub_type

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