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Synthesis, structural properties and insulin-enhancing potential of bis(quercetinato)oxovanadium(IV) conjugate.

Abstract：

:An oxovanadium complex of quercetin (2), exhibits highly potent insulin-enhancing activity in streptozotocin-induced diabetic mice. It also mimics mitogenic potential of insulin as evaluated by [H(3)]thymidine uptake assay making an effective, orally active insulin-enhancing agent for the treatment of both type 1 and type 2 diabetes without any noticeable toxic effects.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Shukla R,Barve V,Padhye S,Bhonde R

doi

10.1016/j.bmcl.2004.07.020

subject

Has Abstract

pub_date

2004-10-04 00:00:00

pages

4961-5

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(04)00911-4

journal_volume

14

pub_type

杂志文章

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