Potent inhibitors of the MAP kinase p38.

Abstract:

:The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-alpha and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

journal_name

Bioorg Med Chem Lett

authors

Henry JR,Rupert KC,Dodd JH,Turchi IJ,Wadsworth SA,Cavender DE,Schafer PH,Siekierka JJ

doi

10.1016/s0960-894x(98)00589-7

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

3335-40

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960894X98005897

journal_volume

8

pub_type

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