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New photocleavable linker: α-thioacetophenone-type linker.

Abstract：

:Photocleavable linkers are advantageous over the common linkers because they could be cleaved without using reagents. A novel photocleavable linker with an α-thioacetophenone moiety has been developed. This linker, which can be cleaved upon irradiation at 365 nm via the Norrish type II reaction, is applicable to a protein affinity purification system, allowing target proteins to be effectively isolated. This novel linker would serve as an effective tool in chemical biology.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Yonezawa H,Nishiyama Y,Takeo K,Iwatsubo T,Tomita T,Yokoshima S,Fukuyama T

doi

10.1016/j.bmcl.2014.04.104

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

2831-3

issue

13

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)00461-2

journal_volume

24

pub_type

杂志文章

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