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Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.

Abstract：

:We report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase (FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Hart T,Macias AT,Benwell K,Brooks T,D'Alessandro J,Dokurno P,Francis G,Gibbons B,Haymes T,Kennett G,Lightowler S,Mansell H,Matassova N,Misra A,Padfield A,Parsons R,Pratt R,Robertson A,Walls S,Wong M,Roughley S

doi

10.1016/j.bmcl.2009.05.097

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

4241-4

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)00787-2

journal_volume

19

pub_type

杂志文章

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