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Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines.

Abstract：

:A small library of 1-aminoalkyl 2-naphthols has been synthesized through the direct Mannich reaction of 2-naphthols with (hetero)aromatic aldehydes and secondary amines. All of the Mannich bases having a thiophen-2-yl ring in their structure had good activity against Gram-positive bacteria, irrespective of the nature of the amino moiety.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Roman G,Năstasă V,Bostănaru AC,Mareş M

doi

10.1016/j.bmcl.2016.03.098

subject

Has Abstract

pub_date

2016-05-15 00:00:00

pages

2498-2502

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(16)30332-8

journal_volume

26

pub_type

杂志文章

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