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In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.

Abstract：

:Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Nersesian DL,Black LA,Miller TR,Vortherms TA,Esbenshade TA,Hancock AA,Cowart MD

doi

10.1016/j.bmcl.2007.10.067

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

355-9

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)01246-2

journal_volume

18

pub_type

杂志文章

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