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Synthesis and structure-activity relationship of potent bicyclic lactam thrombin inhibitors.

Abstract：

:A simple and versatile method for preparation of (D)-Phe-Pro peptidomimetic bicyclic thiazolidine lactams is presented. These bicyclic lactams have chemical diversity alpha to the lactam carbonyl and, when linked to electrophilic arginines, provide potent thrombin inhibitors.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Bachand B,DiMaio J,Siddiqui MA

doi

10.1016/s0960-894x(99)00130-4

subject

Has Abstract

pub_date

1999-04-05 00:00:00

pages

913-8

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(99)00130-4

journal_volume

9

pub_type

杂志文章

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