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Soluble polyphenols: synthesis and bioavailability of 3,4',5-tri(alpha-D-glucose-3-O-succinyl) resveratrol.

Abstract：

:We report the development of a chemical modification method of general applicability to polyphenols, which increases solubility to influence absorption. Glucosyl groups were added to the resveratrol kernel via a succinate linker, yielding 3,4',5-tri-(alpha-D-glucose-3-O-succinyl) resveratrol. The construct was only slowly hydrolyzed in acid and at pH 6.8, but it was destroyed by blood esterases in less than 1h. In rats its administration resulted in a blood concentration versus time curve shifted to longer times in comparison to resveratrol, a useful modulation of pharmacokinetics. The area-under-curve parameter and the metabolite mix were similar to those of resveratrol. The method may be advantageously employed to solubilize other polyphenols and to make them more palatable.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Biasutto L,Marotta E,Bradaschia A,Fallica M,Mattarei A,Garbisa S,Zoratti M,Paradisi C

doi

10.1016/j.bmcl.2009.09.114

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

6721-4

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)01382-1

journal_volume

19

pub_type

杂志文章

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