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Syntheses and antiproliferative evaluation of oxyphenisatin derivatives.

Abstract：

:Syntheses and structure-antiproliferative relationship for oxyphenisatin analogues are described. The cell proliferation data showed that the presence of substituents (especially F, Cl, Me, CF(3), and OMe) in the 6- and 7-position of oxyphenisatin markedly enhanced the potency in the MDA-468 cell line without affecting the MDA-231 cell line. The best compounds from this series showed low nanomolar antiproliferative activity towards the MDA-468 cell line and a 1000-fold selectivity over the MDA-231 cell line.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Uddin MK,Reignier SG,Coulter T,Montalbetti C,Grånäs C,Butcher S,Krog-Jensen C,Felding J

doi

10.1016/j.bmcl.2007.02.060

subject

Has Abstract

pub_date

2007-05-15 00:00:00

pages

2854-7

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00257-0

journal_volume

17

pub_type

杂志文章

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