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2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors.

Abstract：

:The advancement of a series of ligand efficient 2-amino-[1,2,4]triazolo[1,5-a]pyridines, initially identified from high-throughput screening, to a JAK2 inhibitor with pharmacodynamic activity in a mouse xenograft model is disclosed.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Siu M,Pastor R,Liu W,Barrett K,Berry M,Blair WS,Chang C,Chen JZ,Eigenbrot C,Ghilardi N,Gibbons P,He H,Hurley CA,Kenny JR,Cyrus Khojasteh S,Le H,Lee L,Lyssikatos JP,Magnuson S,Pulk R,Tsui V,Ultsch M,Xiao Y,Zh

doi

10.1016/j.bmcl.2013.06.008

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

5014-21

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)00717-8

journal_volume

23

pub_type

杂志文章

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