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2,3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists.

Abstract：

:A novel class of 2,3-diaminopyridine bradykinin B1 receptor antagonists is disclosed. Structure-activity relationship studies (SARs) that led to compounds with significantly improved potency and pharmacokinetic properties relative to the lead compound are described.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Feng DM,Wai JM,Kuduk SD,Ng C,Murphy KL,Ransom RW,Reiss D,Chang RS,Harrell CM,MacNeil T,Tang C,Prueksaritanont T,Freidinger RM,Pettibone DJ,Bock MG

doi

10.1016/j.bmcl.2005.02.077

subject

Has Abstract

pub_date

2005-05-02 00:00:00

pages

2385-8

issue

9

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00271-4

journal_volume

15

pub_type

杂志文章

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