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Design, synthesis, and cytostatic activity of novel cyclic curcumin analogues.

Abstract：

:A series of novel cyclic analogues of curcumin were synthesized and analyzed for in vitro cytostatic activity. Condensation of 2-acetylcycloalkanones with a variety of aromatic aldehydes resulted in the formation of 2-arylidene-6-(3-arylacryoyl)-cycloalkanone derivatives. A number of these analogues were found to have significant anticancer activity against representative murine and human cancer cell lines during in vitro bioassays. This corroborated with in vitro cytostatic activity against a panel of 60 cell lines studied at the National Cancer Institute (USA).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Youssef D,Nichols CE,Cameron TS,Balzarini J,De Clercq E,Jha A

doi

10.1016/j.bmcl.2007.07.079

subject

Has Abstract

pub_date

2007-10-15 00:00:00

pages

5624-9

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00904-3

journal_volume

17

pub_type

杂志文章

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