Synthesis of doxorubicin-peptide conjugate with multidrug resistant tumor cell killing activity.

Abstract:

:Cell penetrating peptide TAT was introduced into doxorubicin structure. Synthesized doxorubicin-TAT conjugate showed different intracellular distribution pattern and cell killing activity from those of free doxorubicin. Unlike free doxorubicin, doxorubicin-TAT conjugate was highly permeable to drug-resistant cells and was able to kill drug-resistant tumor cells efficiently.

journal_name

Bioorg Med Chem Lett

authors

Liang JF,Yang VC

doi

10.1016/j.bmcl.2005.07.087

subject

Has Abstract

pub_date

2005-11-15 00:00:00

pages

5071-5

issue

22

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00984-4

journal_volume

15

pub_type

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