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Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.

Abstract：

:We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Hong Q,Bakshi RK,Palucki BL,Park MK,Ye Z,He S,Pollard PG,Sebhat IK,Liu J,Guo L,Cashen DE,Martin WJ,Weinberg DH,MacNeil T,Tang R,Tamvakopoulos C,Peng Q,Miller RR,Stearns RA,Chen HY,Chen AS,Strack AM,Fong TM,M

doi

10.1016/j.bmcl.2011.02.090

subject

Has Abstract

pub_date

2011-04-15 00:00:00

pages

2330-4

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)00274-5

journal_volume

21

pub_type

杂志文章

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