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Fluorescence detection of serum albumin with a turnover-based sensor utilizing Kemp elimination reaction.

Abstract：

:The Kemp elimination reaction is a well-known chemical reaction that is facilitated on a protein surface microenvironment, and in particular is highly accelerated in a unique binding pocket of serum albumin. We have designed and synthesized a fluorescently activatable coumarin derivative with a benzisoxazole scaffold to enable monitoring of the Kemp elimination reaction in terms of fluorescence change for the first time. We show that this fluorescent sensor can sensitively and selectively quantitate serum albumin in blood samples. It also works in a dry-chemistry format.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Sakamoto S,Komatsu T,Ueno T,Hanaoka K,Urano Y

doi

10.1016/j.bmcl.2017.05.076

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

3464-3467

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(17)30573-5

journal_volume

27

pub_type

杂志文章

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