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Synthesis of 14 C-radiolabeled oligonucleotides with a novel phosphoramidite reagent.

Abstract：

:A novel solid-phase synthesis of 5'-radiolabeled oligonucleotides is described. The labeling reaction is carried out by the phosphoramidite method with the aid of [4,6-di-14C]-5'-dimethoxytritylthymidine building block 1. The feasibility of the method is demonstrated by preparation of 3'-phosphorylated dodecathymidylate phosphorothioate containing radiolabeled nucleoside at the 5'-terminus.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Guzaev A,Boyode B,Balow G,Tivel KL,Manoharan M

doi

10.1016/s0960-894x(98)00028-6

subject

Has Abstract

pub_date

1998-05-05 00:00:00

pages

1123-6

issue

9

eissn

0960-894X

issn

1464-3405

pii

S0960894X98000286

journal_volume

8

pub_type

杂志文章

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