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Chroman-3-amides as potent Rho kinase inhibitors.

Abstract：

:Inhibition of Rho kinase (ROCK) is an attractive strategy for the treatment of diseases such as hypertension, glaucoma, and cancer. Here we report chroman-3-amides as highly potent ROCK inhibitors with sufficient kinase selectivity, excellent cell activity, good microsomal stability, and desirable pharmacokinetic properties for study as potential therapeutic agents.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Chen YT,Bannister TD,Weiser A,Griffin E,Lin L,Ruiz C,Cameron MD,Schürer S,Duckett D,Schröter T,LoGrasso P,Feng Y

doi

10.1016/j.bmcl.2008.10.080

subject

Has Abstract

pub_date

2008-12-15 00:00:00

pages

6406-9

issue

24

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)01283-3

journal_volume

18

pub_type

杂志文章

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