Abstract:
:Model reactions offer a chemical mechanism by which formation of a sulfenyl amide residue at the active site of the redox-regulated protein tyrosine phosphatase PTP1B protects the cysteine redox switch in this enzyme against irreversible oxidative destruction. The results suggest that 'overoxidation' of the sulfenyl amide redox switch to the sulfinyl amide in proteins is a chemically reversible event, because the sulfinyl amide can be easily returned to the native cysteine thiol residue via reactions with cellular thiols.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Sivaramakrishnan S,Cummings AH,Gates KSdoi
10.1016/j.bmcl.2009.12.001subject
Has Abstractpub_date
2010-01-15 00:00:00pages
444-7issue
2eissn
0960-894Xissn
1464-3405pii
S0960-894X(09)01702-8journal_volume
20pub_type
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