Protection of a single-cysteine redox switch from oxidative destruction: On the functional role of sulfenyl amide formation in the redox-regulated enzyme PTP1B.

Abstract:

:Model reactions offer a chemical mechanism by which formation of a sulfenyl amide residue at the active site of the redox-regulated protein tyrosine phosphatase PTP1B protects the cysteine redox switch in this enzyme against irreversible oxidative destruction. The results suggest that 'overoxidation' of the sulfenyl amide redox switch to the sulfinyl amide in proteins is a chemically reversible event, because the sulfinyl amide can be easily returned to the native cysteine thiol residue via reactions with cellular thiols.

journal_name

Bioorg Med Chem Lett

authors

Sivaramakrishnan S,Cummings AH,Gates KS

doi

10.1016/j.bmcl.2009.12.001

subject

Has Abstract

pub_date

2010-01-15 00:00:00

pages

444-7

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)01702-8

journal_volume

20

pub_type

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