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Synthesis, biological evaluation of prenylflavonoids as vasorelaxant and neuroprotective agents.

Abstract：

:A series of prenylflavonoids with multiple hydroxyl groups were synthesized and evaluated for their vasorelaxant activities against rat aorta rings pre-contracted by phenylephrine (PE), as well as their neuroprotective effects against OGD induced PC12 cell injury. The results indicated that the prenyl group at A-ring of prenylflavonoids, as well as hydroxyl groups at B-ring was important for their activities. (+/-)Leachianone G 1b, bearing 8-prenyl and 2',4'-dihydoxyl groups, exhibited the most potent vasorelaxant and neuroprotective effects.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Dong X,Qi L,Jiang C,Chen J,Wei E,Hu Y

doi

10.1016/j.bmcl.2009.04.120

subject

Has Abstract

pub_date

2009-06-15 00:00:00

pages

3196-8

issue

12

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)00630-1

journal_volume

19

pub_type

杂志文章

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