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Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues.

Abstract：

:A novel class of Growth Hormone Secretagogues (GHS), based on a tetrazole template, has been discovered. In vitro SAR and in vivo potency within this new class of GHS are described. The tetrazole 9q exhibits good oral bioavailability in rats and dogs as well as efficacy following an oral 10 mg/kg dose in dogs. Solution and solid phase protocols for the synthesis of tetrazole based GHS have been developed.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Hernández AS,Cheng PT,Musial CM,Swartz SG,George RJ,Grover G,Slusarchyk D,Seethala RK,Smith M,Dickinson K,Giupponi L,Longhi DA,Flynn N,Murphy BJ,Gordon DA,Biller SA,Robl JA,Tino JA

doi

10.1016/j.bmcl.2007.07.099

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

5928-33

issue

21

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00909-2

journal_volume

17

pub_type

杂志文章

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