Abstract:
:The in vitro antimycobacterial activity of cobalt(II) and copper(II) complexes of some fluorinated isonicotinoylhydrazones was evaluated in a TB-infected macrophage model; all metalcomplexes exhibited excellent activity against Mycobacterium tuberculosis Erdman growing within macrophages, at concentrations much lower than in culture media. Moreover complexes 1b and 2a displayed EC(99) values lower than that of the parent-drug, isoniazid. In addition, all tested metalchelates significantly inhibited the growth of single-drug-resistant M. tuberculosis strains; complexes 1a and 2a also possessed moderate activity against Mycobacterium avium complex.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Maccari R,Ottanà R,Bottari B,Rotondo E,Vigorita MGdoi
10.1016/j.bmcl.2004.09.052subject
Has Abstractpub_date
2004-12-06 00:00:00pages
5731-3issue
23eissn
0960-894Xissn
1464-3405pii
S0960-894X(04)01175-8journal_volume
14pub_type
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