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Synthesis, structure and in vitro cytostatic activity of ferrocene-Cinchona hybrids.

Abstract：

:Exploring copper(I)- and ruthenium(II)-catalyzed azide-alkyne cycloadditions and a Sonogashira protocol, novel cytostatic ferrocene-cinchona hybrids were synthetized displaying significant in vitro activity on HepG-2 and HT-29 cells. Preliminary SAR studies disclosed that compounds incorporating linkers with 1,2,3-triazole and chalchone residues can be considered as promising lead structures. According to the best of our knowledge this is the first letter on the incorporation of ferrocene nucleus in the reputed cinchona family via triazole and chalcone linkers with established pharmaceutical profile.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Kocsis L,Szabó I,Bősze S,Jernei T,Hudecz F,Csámpai A

doi

10.1016/j.bmcl.2015.12.059

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

946-949

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)30372-3

journal_volume

26

pub_type

杂志文章

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