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Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity.

Abstract：

:Thieno analogues of the potent and selective furo-pyrimidine anti-VZV nucleoside family bearing a p-alkylphenyl side chain have been synthesised and tested for their antiviral activity against Varicella-Zoster virus (VZV). While the alkyl chain analogues were shown to retain full antiviral activity against VZV, these new analogues did not when compared to their furo parent nucleosides.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Angell A,McGuigan C,Garcia Sevillano L,Snoeck R,Andrei G,De Clercq E,Balzarini J

doi

10.1016/j.bmcl.2004.03.029

subject

Has Abstract

pub_date

2004-05-17 00:00:00

pages

2397-9

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960894X04003828

journal_volume

14

pub_type

杂志文章

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