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Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots.

Abstract：

:(R)-Glycerol-monolinoleate 4 and (R)-glycerol-monostearate 5 were isolated from the ethyl acetate extracts of Saururus chinensis roots and (R)- or (S)-fatty acid glycerols 4 and 5 were synthesized for confirming their structures and evaluating their inhibitory activities against Lp-PLA(2). The (R)-4 and (S)-4 exhibited Lp-PLA(2) inhibitory activities with IC(50) values of 45.0 and 52.0 microM, respectively.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Lee WS,Kim MJ,Beck YI,Park YD,Jeong TS

doi

10.1016/j.bmcl.2005.05.056

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

3573-5

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00666-9

journal_volume

15

pub_type

杂志文章

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