当前位置： SCI文献检索 > BIOORGANIC & MEDICINAL CHEMISTRY LETTERS期刊下所有文献 > The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.

The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.

Abstract：

:The development of a COX-2 inhibitor rofecoxib (MK 966, Vioxx) is described. It is essentially equipotent to indomethacin both in vitro and in vivo but without the ulcerogenic side effect due to COX-1 inhibition.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Prasit P,Wang Z,Brideau C,Chan CC,Charleson S,Cromlish W,Ethier D,Evans JF,Ford-Hutchinson AW,Gauthier JY,Gordon R,Guay J,Gresser M,Kargman S,Kennedy B,Leblanc Y,Léger S,Mancini J,O'Neill GP,Ouellet M,Percival MD

doi

10.1016/s0960-894x(99)00288-7

subject

Has Abstract,Author List Incomplete

pub_date

1999-07-05 00:00:00

pages

1773-8

issue

13

eissn

0960-894X

issn

1464-3405

pii

S0960894X99002887

journal_volume

9

pub_type

杂志文章

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