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Combinatorial peptide microarrays for the rapid determination of kinase specificity.

Abstract：

:We report a rapid method for profiling of kinases using a strategy that couples the merits of combinatorics (in rapid diversity generation) with the throughput attainable using microarrays (in parallel screening). Alanine-scanning, deletion and positional-scanning peptide libraries of a kinase substrate were synthesized and site-specifically arrayed onto glass slides. The phosphorylation pattern of target sequences detected using fluorescently-labeled antiphosphoamino acid antibodies revealed the substrate preference of the kinase through its activity profile.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Uttamchandani M,Chan EW,Chen GY,Yao SQ

doi

10.1016/s0960-894x(03)00633-4

subject

Has Abstract

pub_date

2003-09-15 00:00:00

pages

2997-3000

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960894X03006334

journal_volume

13

pub_type

杂志文章

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