Synthesis of a high-mannose-type glycopeptide analog containing a glucose-asparagine linkage.

Abstract:

:The title compound was prepared by enzymatic transfer of oligosaccharide to a synthetic pentapeptide containing the Glc-Asn linkage. The compound was not hydrolyzed by glycoamidases from plant and bacterial sources, but it inhibited both enzymes in the micromolar range. Its activity is compared to other potential inhibitors.

journal_name

Bioorg Med Chem Lett

authors

Deras IL,Takegawa K,Kondo A,Kato I,Lee YC

doi

10.1016/s0960-894x(98)00306-0

subject

Has Abstract

pub_date

1998-07-07 00:00:00

pages

1763-6

issue

13

eissn

0960-894X

issn

1464-3405

pii

S0960894X98003060

journal_volume

8

pub_type

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