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Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301.

Abstract：

:Two new cyclic octapeptides, mariannamides A (1) and B (2), have been isolated from Mariannaea elegans NBRC102301, a Pinus densiflora-derived filamentous fungus. Their structures were elucidated to be cyclo-(l-Leu1-l-Pro1-l-Pro2-l-Leu2-l-Ile1-l-Pro3-l-Val1-l-Ile2) and cyclo-(l-Leu1-l-Pro1-l-Pro2-l-Leu2-l-Ile1-l-Pro3-l-Val1-l-Val2) based on spectroscopic data and Marfey's method. Mariannamide A (1) promoted mRNA expression of sirtuin 1 (SIRT1) in C2C12 cells, a mouse skeletal muscle myoblast cell line, and showed the antimicrobial activity against Escherichia coli and Cryptococcus neoformans.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ishiuchi K,Hirose D,Kondo T,Watanabe K,Terasaka K,Makino T

doi

10.1016/j.bmcl.2019.126946

subject

Has Abstract

pub_date

2020-02-15 00:00:00

pages

126946

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(19)30932-1

journal_volume

30

pub_type

杂志文章

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