Abstract:
:Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson's disease (PD). The most common mutant, G2019S, increases kinase activity, thus LRRK2 kinase inhibitors are potentially useful in the treatment of PD. We herein disclose the structure, potential ligand-protein binding interactions, and pharmacological profiling of potent and highly selective kinase inhibitors based on a triazolopyridazine chemical scaffold.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Galatsis P,Henderson JL,Kormos BL,Han S,Kurumbail RG,Wager TT,Verhoest PR,Noell GS,Chen Y,Needle E,Berger Z,Steyn SJ,Houle C,Hirst WDdoi
10.1016/j.bmcl.2014.07.052subject
Has Abstractpub_date
2014-09-01 00:00:00pages
4132-40issue
17eissn
0960-894Xissn
1464-3405pii
S0960-894X(14)00776-8journal_volume
24pub_type
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