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Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues.

Abstract：

:In this letter, we describe the first synthesis of two recently isolated flavones 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone (3a), 5-carboethoxymethyl-4',7-dihydroxyflavone (3b) and their derivatives (3c-t), evaluated for their antimicrobial, antioxidant and anticancer activities. Most of the synthesized compounds exhibited antimicrobial activity against the tested microbial strains and some of these compounds were found to be more potent as compared to the standard drugs like neomycin and luteolin. Interestingly, some of these synthesized compounds also showed moderate antioxidant property.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Kamal A,Murty JN,Viswanath A,Sujitha P,Ganesh Kumar C

doi

10.1016/j.bmcl.2012.05.007

subject

Has Abstract

pub_date

2012-07-15 00:00:00

pages

4891-5

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00597-5

journal_volume

22

pub_type

杂志文章

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