Solid-phase synthesis of quinol fatty alcohols, design of N/O-substituted quinol fatty alcohols and comparative activities on axonal growth.

Abstract:

:Following the promising activity of Q2FA15 on axonal growth, two new series of N/O-substituted QFAs were synthesized, based on a SN2-type reaction. O-alkylated QFA bearing 14 carbon atoms on the side chain (n=14) shows a very potent activity on axonal growth though lowered when compared to Q2FA15. While O-alkylation allows good retention of the biological activity, N-alkylation abolishes it nonetheless. A solid-phase-supported synthesis of Q2FA15 allowing the conception of new hybrid compounds is also described.

journal_name

Bioorg Med Chem Lett

authors

Hanbali M,Bagnard D,Luu B

doi

10.1016/j.bmcl.2006.05.027

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

3917-20

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00572-5

journal_volume

16

pub_type

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