Preparation of difluoro analogs of CCGs and their pharmacological evaluations.

Abstract:

:All the stereoisomers of 2-(2-carboxy-3,3-difluorocyclopropyl)glycines (F2CCGs) were synthesized in enantiomerically pure forms using (R)-2,3-O-isopropyl-ideneglyceraldehyde as a chiral precursor. L-F2CCG-I, one of the stereoisomers corresponding to an extended form of L-glutamate was found to be a potent agonist for metabotropic glutamate receptors (mGluRs).

journal_name

Bioorg Med Chem Lett

authors

Shibuya A,Sato A,Taguchi T

doi

10.1016/s0960-894x(98)00338-2

subject

Has Abstract

pub_date

1998-08-04 00:00:00

pages

1979-84

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960894X98003382

journal_volume

8

pub_type

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